Factor VIII (Anti-Hemophilia Factor) (Last Updated - 2/28/2005)

-involved in the intrinsic pathway
-gets activated to form Factor VIIIa via catalysis by Factor IIa (thrombin)
-circulates bound to von Willebrand Factor (vWF)
-if pt. is deficient --> Hemophilia (Type A)

-click here to view an image of the clotting cascade

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References:

Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.